Yes, significantly. Webflow hosts on Fastly's global CDN with 200+ edge nodes, while Squarespace uses a smaller shared infrastructure. More importantly, Webflow outputs clean CSS-grid-based HTML without the render-blocking JavaScript and template overhead that Squarespace generates. In side-by-side Core Web Vitals comparisons, Webflow sites built by Flowtrix consistently achieve LCP under 2.5 seconds and TBT under 200ms — benchmarks that many Squarespace sites cannot reach without compromising design quality.